Here's a study
Yohimbine was applied to one leg. The leg that it was applied to had reduced in size by a greater degree than the control leg.
It has been generally believed for some time that thigh fat in women is hard to mobilize
. Others, however, have been reluctant to accept this concept, believing that all fat cells are metabolically the same
. In vitro work, however, has
suggested that the adrenergic thresholds to lipolysis are indeed different in different sites, and that thigh fat is more
difficult to mobilize than abdomen fat
"Studies 2 and 3 support the concept that topical application of adrenergic modulators can enhance lipolysis. It might have been postulated that yohimbine, the alpha2-inhibitor, would have been the most effective agent, since the
higher threshold for lipolysis in thigh fat cells appears to be a result of a higher concentration of inhibitory alpha2-
The study was done on women. The thigh area in women has a high density of alpha2-receptors which is the cause of the problem. In men these receptors have a high density in the chest abdomen and lower back (love handles).
I am going to buy 16 grams of yohimbine hcl and a transdermal cream and make up my own yohimbine cream. My gf has a lot of fat on her legs and her ass ( I love her ass) and she has a lot of cellulite. We are both going to try it. I will give an update to how it goes when we are finished.