IMHO: Yes you must have a fake email to do Craigslist hookups, and yes stay away from PNP guys, aka guys who use a capiTal T in their texT somewhere (looking for T=tina=crystal meth) or who are looking to go skiing (cocaine) or who have/are looking for favors (drugs).
I go in phases but have definitely observed and used CL for hookups off and on for quite a while and never had a really bad experience. Without really thinking about it until now, I have not had a CL hookup come to my house; I think I'm concerned that if things are going badly I want to be able to just leave, rather than have to attempt to throw someone out. I always meet at their place or at another location.
In general I guess what I would say is, go into your Craigslist hook-up search with an open mind and/or limited expectations. I mean, there are some super hot guys that hook up via Craigslist but they are fewer and further between than we'd all like so don't get your hopes all set on Mr Perfect being the only person who replies to your ad. If you only want to hook up with (say) hot Asians between 28-36, you'll have less luck than if you are just looking for someone who it seems like you might sexually connect with.
Always get a picture, of at least something. If the guy has no pictures, something's seriously amiss.
At least 50% (probably more like 75%+) of responses you get will not ever pan out to be anything, even the ones you are interested in, so now that going in. It's not about you, it's the nature of CL.
Look for travelers / search the listings by "hotel" - those guys are much more likely to be honest and uninhibited (and much less likely to be drug users).
In my experience, CL guys lie mostly about 2 things: their age and their weight. So if he's "45", there's a pretty good chance he's in his 50's. Maybe that bothers you, maybe it doesn't, but that's been my experience. And the weight: I think sometimes guys really think they are still 160 because they were once...they are not trying to deceive you necessarily, they just have deceived themselves into really believing that they are still 160 even though they are 180 now.
I don't respond to ads that would be even mildly inconvenient to get to. I have the luxury of being in an urban area where there are always a bunch of guys looking, but since that's true I am not driving 20 miles to meet up with someone who I might not enjoy THAT much.
Often when I have responded to a guy who looks hot and/or has a big dick he wants to know if I am generous...which means he wants me to pay him to suck that amazing cock. Up to you if you want to do it; I never have. (I can get good dick for free, why pay? Plus, why does he want $65 for a blowjob right now? - in my mind, most logical answer is "so he can go get drugs" which I'm not all about).