Offspring of Older Fathers May Have Subtle Neurocognitive Impairments CME
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March 18, 2009 The offspring of older fathers show subtle impairments on tests of neurocognitive ability during infancy and childhood, according to the results of a study reported in the March 10 issue of PLoS Medicine. "Advanced paternal age (APA) is associated with an increased risk of neurodevelopmental disorders such as autism and schizophrenia, as well as with dyslexia and reduced intelligence," write Sukanta Saha, from Queensland Centre for Mental Health Research, The Park Centre for Mental Health, in Richlands, Australia, and colleagues. "The aim of this study was to examine the relationship between paternal age and performance on neurocognitive measures during infancy and childhood."
*Advanced paternal age is related to poorer neurocognitive measures, and advanced maternal age is related to superior neurocognitive measures in offspring during infancy and childhood.
*Advanced paternal age is linked with scores in the lowest 10% for 3 of the neurocognitive measures: the Bayley Motor Scale, the Graham Ernhart Block Sort Test, and the WISC Full Scale IQ based on logistic regression analyses.
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