Can you get immune to ED medication?

Discussion in 'The Healthy Penis' started by Showerbag, Dec 21, 2009.

  1. Showerbag

    Showerbag Member

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    About 3 years ago I fell while working on a scaffold, and was hanging from my harness for about 30 seconds before i could get my journeyman to find a way to help me up. In that 30 seconds it crushed many little veins and capillaries in my upper legs and pereneum (sp?). I get constant cold feel, numb legs, and just all in all poor circulation in my lower body. I talked to my doctor and Urologist and they gave me a whole slew of drugs to try. Ive tried Cialis 5, 10, 20. Viagra 25, 50, and 100. and Levitra, 10, and 20. The only one that works for me is the Levitra 20, and even then its sub par always semirigid atleast but not super hard for too long at all. After 2.5 years of taking these meds, my lil feller is havin a heck of a time keepin up. Im still semirigid almost the whole time during foreplay and working our way up, but it seems the frequency of it getting very hard are lowering quite a bit. Has anyone else experienced this or know if this is a possibility? I remember asking my doctor a long time ago and he said its very highly unlikely, but its seeming like im in that very tiny %. Anyways thanks guys and ill check back in the morning.
     
  2. prepstudinsc

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    Maybe there is something more serious going on? If you crushed some blood vessels, maybe you damaged some nerves or have some sort of injury to the valves that keep the blood from leaving your dick when it's hard. I think it's time to see a urologist that specializes in erection problems.
     
  3. Industrialsize

    Staff Member Moderator Gold Member

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    I agree, I would go back to the doctor. But to answer your first question, Yes, it is possible to become immune to the effects of certain ED drugs. It has a fancy scientific name which escapes me at the moment.
     
  4. Astrate

    Astrate New Member

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    Sounds like you might have nerve damage? Have you had an MRI of you spine?

    I've heard of ED drugs doing the opposite: after a while the natural response can improve, but I 've not heard of people getting immune to it, But obviously the underlying problem can get worse and therefore the meds become less effective
     
  5. Eisenhower

    Eisenhower Member

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    There can be a problem developing a tollerance to many medications. I would suggest stopping the Levitra for a couple months, then try again. Might need to shake up the body a bit by not having that steady use of medication.
     
  6. Showerbag

    Showerbag Member

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    hmm, yeah i probably should lay off maybe. Im not sure. For a while i was experiencing a pretty decent improvement, but now its just getting worse. and my gf, like all girls, is sorta blaming herself. she thinks im getting bored, but i told her thats not the case. I dont know i should go back for a doctors appointment tho and see if i can get in with the specialist. theres another medication they wanted me to try that involves my penis, and a syringe that goes about a half inch in... I really dont want to do that unless i have to.
     
  7. B_jarod_johansen

    B_jarod_johansen New Member

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    yes, a tolerance is possible but immunity is not the right word as it has nothing to do with the immune system and fighting disease. medications can become less effective over time, requiring more to achieve the same results...this is the tolerance.
    jarod
     
  8. Astrate

    Astrate New Member

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    To be pedantic, "Immune" is used loosely, meaning resistant, e.g. being immune to criticism, or to antibiotics (actually implying bacterial resistance).

    Drug tolerance is common in drugs that are agonists i.e. mimic natural substances in the body by fitting and bind to the same receptors and stimulating them, e.g. morphine, diazepam, but does not occur with drugs that act by inhibition not like paracetamol or anti-inflammatory agents (with some exceptions).

    Viagra et al work by inhibiting the enzyme that breaks down the regulator compound (cGMP) that leads to dilatation of the arteries in the penis, so you would not get tolerance to the drug itself. Theoretically you could get a "down-regulation" through a decrease in numbers of receptors to cGMP because of the repeated high levels. But I have not heard of that happening, even though Cialis has been studied and now marketed as continuous daily dosing, so that you can always be ready.
     
  9. Eisenhower

    Eisenhower Member

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    Good info, Strate, well done. I have read numerous incidents on various forums though of guys for whom Viagra (etc.) has diminished in effectiveness over time, or seemed to stop working. Now, one possibility is that their underlying condition got worse (circulation problems, hormones, etc.) but it's hard to say for sure.

    I think it can't hurt to take a break periodically to let the body take a breather from the drug for a while ... then try it again. Might even be a psychosomatic response, who knows ...

    Eisenhower
     
  10. Showerbag

    Showerbag Member

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    Yeah, i think its actually eating habits and stuff come to think of it. I usually work out regularily and cook good meals and dont smoke as much, but the past couple months with the stresses of school getting higher, and now finally relaxing and not wanting to do anything but veg I've been eating more pizza and chinese and fast food and all the stuff i dont have to prepare because im too busy lately. But today I went for a run, drank lots of water, had 2 smokes today (normally im damn near a pack lately) and It worked quite a bit better today. I think that may be all I need.
     
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