of course p-town is busy and fulll of crazy stuff. There is also whale watching.The towns just south of it are great in the day time for golf and hiking.
Around Orleans it is more of a year round place with a theater and baseball team, which is part of the cape cod summer league, as well as Nauset Beach.
Chatham is very beautiful with a great beach and restaurants.
Hyannis has the most clubs and restaurants. If you stay from Hyannis west it is easier to take the ferry out to MV or Nantucket.
If you stay around Falmouth you can go to Woods Hole, also closest to MV.
Basically it just comes down to what do you want to do. Are you a day person, or a night person?