I was unaware of what missed connections was until a friend brought it to my attention that someone had posted an ad looking for me.
They followed me on the interstate to Starbucks and said I ordered the most complicated drink known to man.
I never responded.
A year later a random guy who works at a bar posted one for me and he turned out to be and still is the most insane person I've met. Ever. He still texts and emails me well after I told him to find a car to chase that I wasn't interested. I'm considering a restraining order at this point.
I search for parts on my car a Del Sol ( not a common car here at least ) using Craigslist and twice I found people posted ads for me when I wasn't even looking at the missed connections. One was a married guy checking out my ass, the other liked me because I drove a "cool car".
So my experience with missed connections is to not respond, I would rather be missed than let a bunch of degenerates know I saw their ads.
I do read them though..