Hi everyone, I'm new on the forum and would like to share with you a theory that maybe, could be applied to have gains in the PE.
DHT is responsible for penis growth in the pre-puberty and puberty, this is because the androgen receptors in the penis are still sensitive, receptors that over time become naturally saturated and down-regulated by the endogenous DHT converted from T.
In males with micropenes who have a deficiency of the enzyme 5 alpha-reductase type 2 where in theory the receptors on the penis have never become saturated during puberty, were treated with topical DHT that surprisingly produced penis growth in all males.
Transdermal dihydrotestosterone therapy and its effects on patients with microphallus. - PubMed - NCBI
Topical dihydrotestosterone to treat micropenis secondary to partial androgen insensitivity syndrome (PAIS) before, during, and after puberty - a c... - PubMed - NCBI
So, why in healthy adults most users who have used DHT like Andractim or similar have not experienced large gains in size?
Because their androgen receptors in the penis have already been saturated and down-regulated over time and therefore their penis have grown.
Following the logic, If you could induce a temporary state where you lower the amount of DHT in your body (with help of Dutasteride or Finasteride) for a period of time sufficient to re-sensitize your androgen receptors in the penis and then up-regulate them, at this point applying topical DHT on the penis, it should attack the androgen receptors that have been up-regulated and made sensitive again, and give a signal to start the growth of the penile tissues, just as it does in the puberty.
There is also a certain Ronielle Buduhan, who has a chemical PE blog , where in a post he says that this method worked mainly for the girth.
Localized Hormone Manipulation for Penis Growth
I have not tried the method now, but I would be willing to do so.
Tell me your opinions.
Thanks everyone.
DHT is responsible for penis growth in the pre-puberty and puberty, this is because the androgen receptors in the penis are still sensitive, receptors that over time become naturally saturated and down-regulated by the endogenous DHT converted from T.
In males with micropenes who have a deficiency of the enzyme 5 alpha-reductase type 2 where in theory the receptors on the penis have never become saturated during puberty, were treated with topical DHT that surprisingly produced penis growth in all males.
Transdermal dihydrotestosterone therapy and its effects on patients with microphallus. - PubMed - NCBI
Topical dihydrotestosterone to treat micropenis secondary to partial androgen insensitivity syndrome (PAIS) before, during, and after puberty - a c... - PubMed - NCBI
So, why in healthy adults most users who have used DHT like Andractim or similar have not experienced large gains in size?
Because their androgen receptors in the penis have already been saturated and down-regulated over time and therefore their penis have grown.
Following the logic, If you could induce a temporary state where you lower the amount of DHT in your body (with help of Dutasteride or Finasteride) for a period of time sufficient to re-sensitize your androgen receptors in the penis and then up-regulate them, at this point applying topical DHT on the penis, it should attack the androgen receptors that have been up-regulated and made sensitive again, and give a signal to start the growth of the penile tissues, just as it does in the puberty.
There is also a certain Ronielle Buduhan, who has a chemical PE blog , where in a post he says that this method worked mainly for the girth.
Localized Hormone Manipulation for Penis Growth
I have not tried the method now, but I would be willing to do so.
Tell me your opinions.
Thanks everyone.