LOTS of differences. You can see this just by looking at photos on the internet!
Obviously there are tight and loose pussies, but there are many more things. Some girls have tiny little pussy lips, others have a great big horse cunt. Length of pussy lips can be something like 2 inches, or as much as 4-5 inches. Some girls have a bigger fat pad or whatever it is, so that their whole pussy area sticks out about an inch or so.
And then there's pussy hair. Some girls shave it all, some shave it all but a thin little line, which is stupid, and others have a great big hairy bush. I like the hairy bush girls best, it is nautral and makes their pussy smell more like it is supposed to.