This is a question I've asked a couple of women before but I thought it would be interesting to hear a more widespread female perspective on the subject. I am eldest of three brothers, with no sisters and although raised predominantly by women, (my dad was merchant navy and away most of the time) I had, I would say, limited contact and understanding of girls in my childhood and young to late teens. They were a mystery and a little scary as my hormones kicked in. What to say? What to do around them? How did they think? Well, I couldn't ask could I? Yet I would look at some of my friends with sisters acting very naturally around girls, seeming comfortable, less self conscious and without the fixed look I felt I had on my face of a boy in the jungle confronted by his first lioness. I guessed it was that they had grown up with a whole different perspective on and attitude towards 'girls'. Obviously they had to wait unil the same age as myself to find their feelings for other girls progressively becoming sexual, but I always thought they started their adventure better equipped to view these strange beings as real people. I quickly picked up the slack thankfully and have always had great relationships with women, whom I love. I've always had a best female friend but I've asked before and I'll ask here too now, is there in your experiences any noticeable difference in guys with and without sisters? Do guys with sisters have more female empathy? Are they more relaxed and expressive with you, even now? I have said to my best friend I would have loved to have had her as a big sis growing up, even just to ask about what makes girls tick. I have wondered if my relationships with women would have differed in any way. Who knows.