While my sexuality on this site is stated as 90% straight and 10% gay, I don't think things are as black and white as that. I'd never be in a relationship with another man, or even date them, but in my past I have had sexual encounters with some of my best friends, but it never changed anything in regards to our friendship. With that said, I haven't done anything with a guy in a VERY long time. I don't seek it either. If it happens, then maybe it will happen, but I love females and vaginal intercourse.
However, I do have gay and out friends. I get jokes from my other friends, insinuating things that aren't true, but generally it's all in good fun. For example, one time I went to lunch with someone who is gay on my lunchbreak, simply because we both loved sushi, and arts and crafts. When we walked back to our place of employment, I got a lot of remarks from my co-workers, but nothing hateful.
A different experience I've had though, is one time I was talking to a gay friend of mine, explaining how I really could use a blowjob. I had been drinking, so I didn't take it the way he took it. He offered to do so for me, but I explained something along the lines of "thanks, but I wouldn't want that to change our friendship". He said it wouldn't, but I still declined. In reality it did and we haven't spoken since other than small talk.
Some of my gay friends are the most awesome friends I have, because they are surprised that I am so open minded, and that I am not ashamed to admit I share some of their musical tastes. But I don't think any less of them because they are gay, nor do I take advantage of them, nor do I hit on them, and they don't hit on me. They are simply my friends.