Here's a study
http://www.mesotherapyworldwide.com...highinObeseWomenafterAdrenergicModulation.pdf
Yohimbine was applied to one leg. The leg that it was applied to had reduced in size by a greater degree than the control leg.
"DISCUSSION
It has been generally believed for some time that
thigh fat in women is hard to mobilize.
Others, however, have been reluctant to accept this concept, believing that all fat cells are metabolically the same. In vitro work, however, has
suggested that the adrenergic thresholds to lipolysis are indeed different in different sites, and that
thigh fat is more
difficult to mobilize than abdomen fat. "
"Studies 2 and 3 support the concept that topical application of adrenergic modulators can enhance lipolysis. It might have been postulated that yohimbine, the alpha2-inhibitor, would have been the most effective agent, since
the
higher threshold for lipolysis in thigh fat cells appears to be a result of a higher concentration of inhibitory alpha2-
receptors"
The study was done on women. The thigh area in women has a high density of alpha2-receptors which is the cause of the problem. In men these receptors have a high density in the chest abdomen and lower back (love handles).
I am going to buy 16 grams of yohimbine hcl and a transdermal cream and make up my own yohimbine cream. My gf has a lot of fat on her legs and her ass ( I love her ass) and she has a lot of cellulite. We are both going to try it. I will give an update to how it goes when we are finished.