Here's some boring info about growth hormone.
@SilicateWielder @Jordansworld98 @cockydude2018
Secretion of growth hormone (GH) in the pituitary is regulated by the
neurosecretory nuclei of the
hypothalamus. These cells release the peptides
Growth hormone-releasing hormone (GHRH or
somatocrinin) and
Growth hormone-inhibiting hormone (GHIH or
somatostatin) into the
hypophyseal portal venous blood surrounding the pituitary. GH release in the pituitary is primarily determined by the balance of these two peptides, which in turn is affected by many physiological stimulators (e.g., exercise, nutrition, sleep) and inhibitors (e.g., free fatty acids) of GH secretion.
[12]
Somatotropic cells in the
anterior pituitary gland then synthesize and secrete GH in a pulsatile manner, in response to these stimuli by the hypothalamus. The largest and most predictable of these GH peaks occurs about an hour after onset of sleep with plasma levels of 13 to 72 ng/mL.
[13] Otherwise there is wide variation between days and individuals. Nearly fifty percent of GH secretion occurs during the third and fourth
NREM sleep stages.
[14] Surges of secretion during the day occur at 3- to 5-hour intervals.
[3] The plasma concentration of GH during these peaks may range from 5 to even 45 ng/mL.
[15] Between the peaks, basal GH levels are low, usually less than 5 ng/mL for most of the day and night.
[13] Additional analysis of the pulsatile profile of GH described in all cases less than 1 ng/ml for basal levels while maximum peaks were situated around 10-20 ng/mL.
[16][17]
A number of factors are known to affect GH secretion, such as age, sex, diet, exercise, stress, and other hormones.
[3] Young adolescents secrete GH at the rate of about 700 μg/day, while healthy adults secrete GH at the rate of about 400 μg/day.
[18] Sleep deprivation generally suppresses GH release, particularly after early adulthood.
[19]
Stimulators of growth hormone (GH) secretion include:
Inhibitors of GH secretion include:
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