Probably weird to speculate about the sexuality of a fictional character, but I've noticed that there are some gay things going on with Quagmire. There's one scene where Peter visits, and there is a naked guy riding a tracter in Quagmire's house; Quagmire says, "My family is over and we're playing.... sex." In another scene, Peter has to give Quagmire a cavity search, and he finds all sorts of things up Quagmire's ass. There's another scene where Quagmire is naked, and he shakes his penis around in front of Peter. Here and there, there are little things about Quagmire that seem gay.