It's Liza, what's not to love?
Is she medicated or just being her eccentric self while wrapped in her insecurity blanket? It's not easy to tell; but I don't believe she's on anything (and hope not).
As to directing the models, hey, it's her right to do so, especially when considering it is a fashion line with her name attached. She want's the garments and jewelry to look the absolute best.
Besides which the damn thing (the youtube clip) is choppy and clipped, edited, with several pieces of her appearance interspersed, jumping from one segment to another, which would make anyone seem off kilter.
The only thing which appeared off was the first caller, 'Doris in Georgia' to whom Liza says, 'Hi Georgia', it then zips into a different section of the program (note the countdown clock went from twenty some odd seconds to more than 30 seconds on a different item) which makes her comment seem strange.
She's fine and fabulous as always.