There are many others, but I think that Mr. Holland's Opus deserves mention in this thread. His one desire was to be a professional composer, and music is his life. He takes what he thinks will be a temporary job (teaching, which slowly becomes the most important thing in his life,) has a (deaf) son whom he doesn't figure out how to relate to, or even communicate with, until his life is almost over. One of the almost unbearably crushing scenes is where he is arguing with his wife over what school to send their son to; she wants a signing school (considerably more expensive) or an oral school that their doctor recommended. She breaks down, crying, on the kitchen floor, and tells him something along the lines of "you get to go to school every day and spend time with your kids, and I can't even tell my own son I love him!"