The only time it bothers me is when NJQT says something that's clearly a matter of her own opinion, not a well known fact, or even factually incorrect in response to someone's often reasonable question and tags it with the :duh: icon. It's base and insulting, and she says enough :bsflag: that her overuse is highly ironic.
That's the only time the smileys grind my gears, so overall I don't have a problem. Well, that and the fact that the :bsflag: flag destroys the flow of posts