Fibrosis is the formation of collagen in response to damage. The collagen that is produced is much tougher than normal collagen. This can have a negative effect on penis enlargement. When we stretch, bend, clamp, compress, jelq, uli, pump, etc. we are trying to increase the number of cells contained within the penis. Collagen is not a cell - it is extracellular. The increase in tough collagen makes it tougher to do these exercises. In normal PE we try to increase the cells contained within the penis but not go overboard and end up producing too much collagen which would hinder future gains. This can be a long slow process. It can take years of trail and error just to get a couple of inches of growth. Many believe the tunica to be the main limiting factor in PE. The Tunica consists of 95% collagen. I believe that the reason why newbies gain so much is due to the tunica being weak as well as the increase in EQ that they get. What if we could use maximum intensity (without causing injury) but prevent the formation of tough collagen? Inflammation seems to be involved in fibrosis with some anti inflammatory drugs preventing fibrosis. I am going to try applying ibuprofen gel 2 to 3 times a day for the next month to see if it helps with penis enlargement. One very interesting drug it Potaba. It is used in the treatment of peyronies disease. It acts as an anti-fibrotic and anti-inflammatory. I've started this thread in order to find out other possible anti-fibrotics and whether people think that they are actually of benefit to PE.