I'm not going to make a big post responding to every point in particular. Inbreeding is deleterious generally. Any advantages passed on are far outweighed by the increased mortality.
Stop and think about that. How exactly did we evolve? By inbreeding? I think we did. It works. It generates a greater range of gene expression and hence speeds up selection.
I already told you the example of it in the sickle cell trait and malaria. People aren't selected to have sickle cell anemia. They're selected to be heterozygous for the sickle cell trait. That seems to be your confusion.
i thought I introduced it into the discussion as an example of an apparently bad genetic trait which in fact is beneficial.
It's not on the negative side to prove something, it's on the positive side.
I merely observed that it is a mistake to base scientific conclusion on what is reported in the news. 'Man dies from rare genetic disease' may draw attention and clock up 1 score against inbreeding, but so what? 'man fails to catch HIV despite unknowingly being exposed and no one knowing he had the rare homozygous pair which protected him' just never appears in print. How could it? No one would know. It is impossible to draw any scientific conclusion if you do not properly analyse a situation. You cannot conclude anything about the relative frequency of bad traits from inbreeding unless you can quantify the accompanying frequency of good traits.
You're insisting there are common genetic causes for infertility. I asked you for proof of it because, as someone who would know about them, I have not heard of them. You don't have any. Therefore, your stance holds no water.
Are you denying that the bodies immune system and general ability to fight off invading organisms has anything to do with genetic inheritance? ?? You are attempting to take a very narow view of what counts as an inherited genetic deficiency, which is not sustainable. I infer you are prefessionally a medic of some sort, so come on, apply some medical common sense.
I'm struggling not to be overly condescending with you, but you're not making it easy. You need to recognize that you're arguing with me on my turf.
Then maybe you should answer more seriously, because thus far a guy having read half of Dawkins' books 10 years ago is making you look not so good. My advice would be to stop being condesending and answer in depth, but avoid technical terms which will only serve to confuse the layman.
Unless you start saying something that's scientifically, genetically accurate, there's unlikely to be an accord here.
Indeed. Including over what is scientifically accurate.
Where did I say "new variation"? I was responding to your point about evolution, not discussing new variants. My response, verbatim:
Actually, no. The vast majority of evolution is caused by variations that are already present in the genome being selected for or against, not by random mutation.
Again, you seem to be taking a very narrow definition of the meaning of 'evolution'. Evolution is a process. The first step of that process is for a new genetic variant to appear randomly. Then this spreads through the population. If it is a bad trait, it may die out. or, it may become widespread because it confers an immediate benefit. Evolution in action. Then again, it may simply exist as a variation because it is not immediately good or bad. Given a new stimulus, it may now suddenly come into its own because it confers a benefit in the new situation. You are looking at only part of the picture. Species tend to change in spurts, but the evolutionary process proceeds steadily.
Dandelion said:
But this is deliberate inbreeding generation after generation, not the odd sibling marriage which is all that is remotely likely if people are left to choose.
Guy-jin said:
It could happen after one generation. Very possible. The offspring of a sibling-sibling mating has 25% homozygosity. In other words, it has lost 25% of its protection against deleterious inherited alleles. Russian roulette. Have four children and one of them is very likely to die or have a genetic disease. In fact, there's a good chance you'll end up with a number of miscarriages before you even have a child in that joining.
Dandelion said:
We all die from a genetic disease. faulty hearts, faulty livers, cancerous cells, faulty immune system, something fails and few survive more than 100 years. Show me the genotype for living 200 years and I want to inbreed it at once. The numbers I have heard discussed suggest you way over estimate the effect.
Guy-jin said:
What in Darwin's name are you even talking about? How is that at all relevant to the quote you are supposedly responding to?
Hope I traced the conversation correctly. You were arguing that inbreeding causes immediate bad effects, I was arguing that all life is genetically organised and we all suffer from bad genetic effects. If we manage to survive most of the specific ones, we still die before a maximum age of around 100. In fact, living to 100 may well mean we had a particularly good genetic deal and avoided most of the obvious bad ones, but we still had a bad genetic inheritance which caused us to die at 100. So dont claim inbreeding makes for uniquely bad traits, we all have plenty already. If a random variation suddenly occurs which when doubled up makes us live 200 years, i want to inbreed for that trait as soon as possible, because it is very desireable. If we forbid inbreeding we will never see the effect and never benefit by the extra 100 years life.
Look, I'm trying to help people understand why incest is genetically a bad thing. I'm a professional geneticist. I know what I'm talking about. I don't think you are a geneticist, and if you are, I think you need to brush up on your genetics.
Well I think you are wrong. Evolution has led to improvements in the species, any species. That is what it does, how it works. We know it works because we are here arguing about it. Inbreeding (incest) helps spread new traits faster, allows them to be expressed. If this is prevented, then evolution is also being curtailed and prevented. You are arguing to prevent one element of evolution continuing. I imagine that most random genetic variations are in fact bad, because the current set are all ones which basically work and to make a random change may very well screw something up. But in the context of incest we are talking about pairing up genes which are relatively common in the population (or the parents would anyway be unlikely to possess them) and so are already proven to be of some benefit (or they would have been bred out). I see no reasoon to think such a doubling up is any more likely to be disadvantageous than advantageous.