Are you asking if I avoid talking to a friend whom I know is not straight about their relationships and love lives BECAUSE of differences in our sexuality?
Nope. If you bring it up, I'll let you talk about and I'll ask questions that seem appropriate. How long have you known each other? Are you going on a date? Do you want an exclusive relationship? That kind of stuff. One of my (few) gay friends (that I have and am aware of their sexuality) does get a bit "much" sometimes when he keeps stopping mid-conversation to ogle some college guy walking down the street, but I just sorta roll my eyes and let him go on. In fairness, I do the exact same thing when fellow straight friends try too hard to respond to attractive women; it's equally annoying.
I'm indiscriminate when it comes to getting annoyed. And, truth told, fellow straight guys can be really annoying about this too. You don't need to try so hard or prove yourself to me. And if your goal is to get laid while we're having a drink, unless I'm specifically asked to serve on wingman duty, then you can do your own thing.
But I'll add this. You said in the OP that to avoid this drama you'd even pretend to find women attractive, right? Seriously? Why the fuck for? I get NOT wanting to make a big deal of a relatively harmless social fact (you liking other guys), but I don't get the extra production. If you have to do all that to hang with a friend, then they better have something extra magical about them; otherwise, it isn't worth all this nonsense. You're also not obligated to wear rainbow everything and fawn all over dudes, gay and not. Look, man, just be yourself. You deserve that much.