Made-up words like irregardless (I would ask whether or not I spelled that correctly, but I really don't care).
Certain phrases irritate me, such as "it's always something". Of course, "it's always something", otherwise it would be nothing. Oblivion! A non-event mass with a quantum probability of zero! Is this some paranoid psychological affliction that one thinks they are so important that the universe is intent on destroying them? Just because they feel that they are a pawn of fate does not give them the right to share their victimhood with me.