Ha ha ha! Yeah I have 2 office wives, well I no longer work with one of them, but we're still really close and though she is married people quite frequently thought we were an item around the office.
I'm really close with the Office Admin. at my office, we just clicked from her 1st day at the office when she was being trained by my "former office wife". We talk very openly about family, friends, relationships and we go to lunch and sometimes dinner together. I ride in her car, she rides in mine from time to time.
We know each others habits so well that if one of us doesn't seem like our usual selves we can tell in seconds, and we'll talk to each other in person or via Blackberry Messenger, although it might take our co-workers a little time and explaining for them to catch on. Guys around the office try calling her "babe" and hit on her and she'll tell them what they can go do with themselves if they ever try that again, but I can walk up to her and say "Hey beautiful, I'm going to get something to eat, wanna join me?" and she'll jump at the chance.
Yesterday I decided not to talk to her for the latter half of the day because she called me "evil" jokingly because I told her I was recording her on video camera when I really wasn't. So I kept up the joke and stayed silent around her and our co-workers started asking if we weren't talking which we thought was hilarious. At the end of the day when she was leaving she was asking me for my opinion on something and I said nothing! I BBM'd her with my opinion afterwards and told her that I thought her hair looked really amazing today, but I couldn't tell her that after she called me evil.
As long as the work spouse relationship doesn't get in the way of an already-in-progress relationship I don't see any problems.