2009 study finding D3 and K2 increases penis size

[deleted18278]

It isn't a very high quality study and the sample size is small, none the less I thought you guys might find it interesting. I searched up didn't find it so I don't think this is a repost.

https://www.researchgate.net/public...ed_Growth_of_the_Adult_Penis_With_Vitamin_D_3

 

[deleted18278]

Related literature suggests VitD improves testosterone and erection quality
Vitamin D and Male Sexual Function: A Transversal and Longitudinal Study

While K2 removes calcium deposits and helps deposit it on bones. Perhaps K2 is helping to remove calcification (plaque) that prevents full penis expansion. I don't know...or maybe it is bunk.

https://www.lifeextension.com/magazine/2017/11/vitamin-k-and-arterial-stiffness

 

[engineer805]

The 50,000 unit daily dose of D3 in the study is off the charts and considered toxic! To wit:
"
Since relatively little is known about how vitamin D toxicity works, it’s hard to define an exact threshold for safe or toxic vitamin D intake (5Trusted Source).

According to the National Academy of Medicine, formerly known as the Institute of Medicine, 4,000 IU is the safe upper level of daily vitamin D intake. However, doses up to 10,000 IU have not been shown to cause toxicity in healthy individuals (11Trusted Source, 16Trusted Source).

Vitamin D toxicity is generally caused by excessive doses of vitamin D supplements, not by diet or sun exposure (17Trusted Source, 18Trusted Source).

Although vitamin D toxicity is a very rare condition, recent increases in supplement use may lead to an increase in reported cases.

A daily intake ranging from 40,000–100,000 IU (1,000–2,500 mcg), for 1 to several months, has been shown to cause toxicity in humans (15Trusted Source, 19Trusted Source, 20Trusted Source, 21Trusted Source, 22Trusted Source).

This is 10–25 times the recommended upper limit, in repeated doses. Individuals with vitamin D toxicity usually have blood levels above 150 ng/mL (375 nmol/L).

Several cases have also been caused by errors in manufacturing, when the supplements had 100–4,000 times higher amounts of vitamin D than stated on the package (19Trusted Source, 20Trusted Source, 23Trusted Source).

The blood levels in these cases of toxicity ranged from 257–620 ng/mL, or 644–1549 nmol/L.

Vitamin D toxicity is usually reversible, but severe cases may eventually cause kidney failure and calcification of the arteries (24Trusted Source, 25Trusted Source)."

Cited from:
How Much Vitamin D Is Too Much? The Surprising Truth

Holistic medicine indeed!!

 

[engineer805]

I think the inclusion of K2 in the "treatment" is an attempt to prevent the calcification of blood vessels (and kidneys) caused by the excess D3. I sure wouldn't take the risk - pumping is a safer, albeit slower, way to get there - and can easily exceed the 1/2" gains reported in this study. What would really be interesting is to do a long-term follow-up on any of these volunteers who continued the treatment. And there's no mention of whether results were permanent or temporary ...

 

[ericbear]

The 50,000 unit daily dose of D3 in the study is off the charts and considered toxic! To wit:
"
Since relatively little is known about how vitamin D toxicity works, it’s hard to define an exact threshold for safe or toxic vitamin D intake (5Trusted Source).

According to the National Academy of Medicine, formerly known as the Institute of Medicine, 4,000 IU is the safe upper level of daily vitamin D intake. However, doses up to 10,000 IU have not been shown to cause toxicity in healthy individuals (11Trusted Source, 16Trusted Source).

Vitamin D toxicity is generally caused by excessive doses of vitamin D supplements, not by diet or sun exposure (17Trusted Source, 18Trusted Source).

Although vitamin D toxicity is a very rare condition, recent increases in supplement use may lead to an increase in reported cases.

A daily intake ranging from 40,000–100,000 IU (1,000–2,500 mcg), for 1 to several months, has been shown to cause toxicity in humans (15Trusted Source, 19Trusted Source, 20Trusted Source, 21Trusted Source, 22Trusted Source).

This is 10–25 times the recommended upper limit, in repeated doses. Individuals with vitamin D toxicity usually have blood levels above 150 ng/mL (375 nmol/L).

Several cases have also been caused by errors in manufacturing, when the supplements had 100–4,000 times higher amounts of vitamin D than stated on the package (19Trusted Source, 20Trusted Source, 23Trusted Source).

The blood levels in these cases of toxicity ranged from 257–620 ng/mL, or 644–1549 nmol/L.

Vitamin D toxicity is usually reversible, but severe cases may eventually cause kidney failure and calcification of the arteries (24Trusted Source, 25Trusted Source)."

Cited from:
How Much Vitamin D Is Too Much? The Surprising Truth

Holistic medicine indeed!!

There may be a little confusion about the dose of Vitamin D. The study says it used a dose of 50,000 to 100,000 IU weekly (or even less frequently), not daily. This would be an equivalent daily intake of about 7,000 to 14,000 IU, assuming a weekly dose.

I still thought it odd to give a huge bolus of D at weekly intervals, rather than the usual daily supplement I am familiar with. However, I looked into the prescribing information for cholecalciferol oral solution, and found it is indeed used this way. For example, Sanofi markets a 60,000 IU per dose oral solution (actually a suspension of oily droplets) for weekly administration under the name DePURA. A similar product with the same dosage is Novel-D3. These drugs are marketed for ordinary use in cases of Vitamin D deficiency, not for some special application. I'm not quite sure why this large dose does not immediately cause toxicity, but I suspect it may be because D3 is extremely soluble in fat, and might be sequestered in the fatty tissues and slowly released. In any event, treatment of Vitamin D deficiency by a huge oral bolus at intervals of a week to a month appears to be common practice in some countries, while in the USA daily small doses seems to be the norm. I note that the sexual study appears to have been conducted in Italy, where perhaps the bolus method is used.

 

[engineer805]

ericbear, thanks for pointing out my error in missing the stated weekly dosing ... as well as the other interesting info about D3!

 

[autoballer]

The study is 50k iu d3 daily, Not weekly, but showed that as long as you avoid calcium supplements then no issues were reported. I'm going for it. The results were for 3 months or 6 months depending on which one has an * most of the change is in the first 3 months they reported. I will continue to pump, traction, and supplement as well.

 

[ericbear]

The study is 50k iu d3 daily, Not weekly, but showed that as long as you avoid calcium supplements then no issues were reported. I'm going for it. The results were for 3 months or 6 months depending on which one has an * most of the change is in the first 3 months they reported. I will continue to pump, traction, and supplement as well.

You cite multiple studies. The one that actually made it into a peer-reviewed journal (as opposed to self-published) says this:

Be careful.

 

[tripod]

Also let’s be real in that Vitamin D is not only predominantly metabolized in the liver but a healthy liver can store an enormous amount of Vitamin D… enough for four months.

Most of the cases of Vitamin D toxicity were from mislabeling or manufacture error where inordinate amounts of Vitamin D were administered to children or the elderly.

Despite widespread Vitamin D supplementation, 1 in 4 Americans are still deficient

let’s also be real in that Hypercalcemia does not depend upon exogenous Calcium intake but can leach Calcium from our bones… making them weak.

Blood tests for vitamin and mineral levels are quite affordable. I urge anyone thinking about taking Vitamin D to take bloodwork before beginning supplementation. Even if you decide to move forward with supplementation, you will at least have a baseline with which to decide if the supplementation is efficacious or harmful.