I don't know if anyone is going to be able to give me any help on this or not, but I thought I would give it a try. For the past 5 1/2 months I have been treated with an immunosuppressant medication for an autoimmune disorder. The medication is Cytoxan (cyclophosphamide). This medication is also used in the treatment of some cancers. One of the side effects of this medication is testicular atrophy (shrinking balls). I wish I would have been warned about this side effect, but that is really irrelavent since the medication still needed to be taken. So far my balls have decreased in size by about 30%. At my next doctor's appointment I know that the medication is going to be changed to a less aggressive immunosuppressant. I have already checked and testicular atrophy is not a side effect. My question is, Will the atrophy resolve automatically, allowing my balls to return to their previous size :smile: , or this this change a permanent one ?